Many behaviors in children diagnosed with autism spectrum disorder (ASD) resemble ﬁght-or-ﬂight avoidance responses resulting from habitual states of fear, possibly induced by sensory processing issues, causing on-going stress and deregulation of systemic pacing. This study hypothesized that patterned, tempo-based, rhythminterventions,at60-beatsperminute(bpm), can regulate and induce systemic pacing, reduce repetitive anxiety behaviors and enable focus and calm in persons with ASD. Eight-week pilot study investigated the inﬂuence of four sensorimotor rhythm interventions for habituation (entrainment) of systemic inner rhythms, pacing, stress, anxiety, and repetitive behavior reduction, ultimately yielding eye-contact, attention, motor planning, and memory. Six subjects(n=6) ages 8-12, with ASD and minimal expressive language, were treated in 45-minute weekly one-on one music therapy session, over eight weeks. A rating scale tracked responses and progress in vivo per session, and on video-tape. Life shirt heart-monitor vest with embedded wireless sensors, worn by each subject during the ﬁrst, ﬁfth and eight sessions, tracked heart-rate data. Results support the hypothesis that highly structured rhythmic interventions at a slow tempo can yield levels of systemic pacing, motor planning, visual contact, attention, reduction of anxiety and repetitive behaviors, and functional adaptation.