History and uses of the Native American Flute.  The Native American flute has been reported as the third oldest instrument dating back 60,000 years.  Most flutes were made of an organic material such as cedar, cane bamboo or reed.   River reed was used to make flutes in the southern part of the U.S.  This was an easy flute to make which became the plains flute style, which has been the most common flute today.