Clinical Research Paper Database
The papers are organized based on the following categories:
Title
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Title
Stability and plasticity of auditory brainstem function across the lifespan
Description
The human auditory brainstem is thought to undergo rapid developmental changes early in life until age ∼2 followed by prolonged stability until aging-related changes emerge. However, earlier work on brainstem development was limited by sparse sampling across the lifespan and/or averaging across c...
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Title
A Little Goes a Long Way: How the Adult Brain Is Shaped by Musical Training in Childhood
Description
Playing a musical instrument changes the anatomy and function of the brain. But do these changes persist after music training stops? We probed this question by measuring auditory brainstem responses in a cohort of healthy young human adults with varying amounts of past musical training. We show t...
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Title
Auditory brainstem response to complex sounds: A tutorial
Description
This tutorial provides a comprehensive overview of the methodological approach to collecting and analyzing auditory brainstem responses to complex sounds (cABRs). cABRs provide a window into how behaviorally relevant sounds such as speech and music are processed in the brain. Because temporal and...
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Title
Musical experience and the aging auditory system: Implications for cognitive abilities and hearing speech in noise
Description
Much of our daily communication occurs in the presence of background noise, compromising our ability to hear. While understanding speech in noise is a challenge for everyone, it becomes increasingly difficult as we age. Although aging is generally accompanied by hearing loss, this perceptual decl...
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Title
Musicians change their tune: How hearing loss alters the neural code
Description
Individuals with sensorineural hearing loss have difficulty understanding speech, especially in background noise. This deficit remains even when audibility is restored through amplification, suggesting that mechanisms beyond a reduction in peripheral sensitivity contribute to the perceptual diffi...
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Title
Musical experience strengthens the neural representation of sounds important for communication in middle-aged adults
Description
Older adults frequently complain that while they can hear a person talking, they cannot understand what is being said; this difficulty is exacerbated by background noise. Peripheral hearing loss cannot fully account for this age-related decline in speech-in-noise ability, as declines in central p...
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Title
Musical experience offsets age-related delays in neural timing
Description
Aging disrupts neural timing, reducing the nervous system's ability to precisely encode sound. Given that the neural representation of temporal features is strengthened with musical training in young adults, can musical training offset the negative impact of aging on neural processing? By compari...
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Title
Audiovisual deficits in older adults with hearing loss: Biological evidence
Description
Objective: To examine the impact of hearing loss (HL) on audiovisual (AV) processing in the aging population. We hypothesized that age-related HL would have a pervasive effect on sensory processing, extending beyond the auditory domain. Specifically, we predicted that decreased auditory input to ...
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Title
Continued maturation of auditory brainstem function during adolescence: A longitudinal approach
Description
Cross-sectional studies have demonstrated that the cortical auditory evoked potential (CAEP) changes substantially in amplitude and latency from childhood to adulthood, suggesting that these aspects of the CAEP continue to mature through adolescence. However, no study to date has longitudinally f...
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Title
Music training: Lifelong investment to protect the brain from aging and hearing loss
Description
Age-related declines in the auditory system contribute strongly to older adults’ communication difficulties, especially understanding speech in noisy environments. With the aging population growing rapidly there is an expanding need to discover means to offset or remediate these declines. Music t...
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Title
Absent auditory brain stem response: Peripheral hearing loss or brain stem dysfunction?
Description
Interpretation of auditory brain stem response (ABR) findings can be problematic in cases where waves III and V are absent. Such findings can be attributed to profound hearing loss, brain stem neuropathology, or both. Over a 3-year period, 48 patients with no known brain stem damage and on whom a...
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Title
Auditory processing disorder: Biological basis and treatment efficacy
Description
Auditory processing disorders contribute to communication difficulties in children with language-based learning impairments and in older adults who have trouble hearing in background noise. Therefore, deficits in auditory processing are widespread among these diverse populations. For this reason,...
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Board Members: David Gibson, Randy Masters, Jennifer Catalano, Lisa Lippincott, Jackie Miller, Anders Christensen